Endocrine Abstracts

A retrospective analysis of the results of all intra-arterial calcium stimulations performed at St. Vincent’s Hospital, Dublin, in the years 2001-2006. All patients with symptoms suggestive of hypoglycemia had 72 hour fasting test with evidence of inappropriately elevated insulin and c-peptide at the time of hypoglycemia. These patients were investigated further with pancreatic imaging and selective intra-arterial calcium stimulation with hepatic venous sampling (ASVS). A...

Introduction: Anti-cytokine therapy may be useful for the treatment of active thyroid associated ophthalmopathy (TAO). We aimed to establish the effects of selected cytokines on intercellular adhesion molecule 1 (ICAM1) expression and adipogenesis in orbital fibroblasts (OFs) from patients with and without TAO.Methods: Orbital tissue was taken during surgery from 5 patients with TAO and 5 control subjects. Primary cultures of OFs were established and sta...

Neuropeptide Y (NPY) is a centrally expressed peptide with potent orexigenic properties, released post-prandially to stimulate appetite, regulated by insulin and altered by obesity. NPY is expressed in adipose tissue which suggests it may have a potential effect on altering appetite control in obesity. To date no study has investigated NPY and its regulation in human adipose tissue. Therefore, the aims of this study were to 1) determine the depot-specific expression in abdomin...